Statin therapy on dementia in elderly type 2 diabetes patients with delirium.

ABSTRACT:

Background

Diabetes-related delirium presents a significant challenge in older adults with type 2 diabetes mellitus (T2DM) due to its strong association with cognitive decline and increased dementia risk. Statins, known for their lipid-lowering and neuroprotective properties, may reduce this risk, but their impact in high-risk populations like older T2DM patients with a history of delirium is not fully understood.

Methods

The study included individuals aged 65 and older with T2DM and a history of hospitalization for delirium between January 1, 2008, and December 31, 2019, with follow-up until December 31, 2022. Statin use was defined as at least 28 cumulative defined daily doses (cDDD) per year. Propensity score matching (PSM) was used to balance baseline characteristics bet

SUBMITTER: Sun M 

PROVIDER: S-EPMC12723942 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature