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Multi-omics dissection of the genetic regulation underlying fatty acid composition in cattle.

ABSTRACT:

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12723948 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature

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Multi-omics dissection of the genetic regulation underlying fatty acid composition in cattle.

Zhang Tianliu T   Niu Qunhao Q   Wang Tianzhen T   Wu Jiayuan J   Zhu Bo B   Wang Zezhao Z   Gao Xue X   Chen Yan Y   Gao Huijiang H   Zhang Lupei L   Fu Tong T   Gao Tengyun T   Liu George E GE   Li Junya J   Xu Lingyang L  

Genome biology 20251222 1

BACKGROUND: Fatty acid composition is a complex trait governed by a polygenic architecture. Although numerous genetic variants associated with fatty acids have been identified through genome-wide association studies (GWAS), the underlying regulatory mechanisms remain incompletely understood. In this study, we employed a multi-omics approach to deeply dissect the genetic regulation of fatty acids in cattle. RESULTS: Our integrated multi-strategy GWAS framework identifies 118,697 candidate variant  ...[more]

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