A novel regulatory circuit of ATG4B and SESN3 promotes T cell leukemogenesis.

ABSTRACT:

Background

T cell acute lymphoblastic leukemia is a fatal hematological malignancy. Despite the treatment progress, no targeted therapy is available currently, which urges to deepen the understanding of the underlying mechanism of T-ALL cell growth/survival. Autophagy is a conserved cellular process, which plays a dual role in human cancers. Nevertheless, many aspects of the involvement of autophagy in T-ALL are not fully understood.

Methods

T-ALL patient cells and normal control cells were subjected to RT‒qPCR analysis. Gene silence and overexpression was used to study the function of ATG4B and sestrin 3 (SESN3) in T-ALL cells. Atg4b deficient mice were used to study the role of Atg4b in normal hematopoietic cells and T cell development. The efficacy of S130, an ATG4B inhib

SUBMITTER: Ma W 

PROVIDER: S-EPMC12723951 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature