A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.

ABSTRACT: Obsessive-compulsive disorder (OCD) manifests with diverse symptom constellations that likely arise from dysfunction in partially distinct neural circuits. Deep brain stimulation (DBS), paired with highresolution connectomics, offers a unique window into these pathways in humans. Here, we analyzed clinical outcomes and stimulation sites from 77 treatment-refractory patients with OCD and 39 with Tourette's syndrome (TS) exhibiting comorbid obsessive-compulsive behaviors (244 electrodes across 15 cohorts and eight targets). Engagement of the previously defined OCD response tract predicted global obsessive-compulsive symptom improvement across heterogeneous targets and diagnoses, spanning both OCD and TS. Beyond broad symptoms, obsessions, compulsions, anxiety, and depression mapped on

SUBMITTER: Hollunder B 

PROVIDER: S-EPMC12723968 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature