A sparse proteomic risk score incorporating plasma MMP12 level improves prediction of abdominal aortic aneurysm.

ABSTRACT:

Background

Screening criteria for abdominal aortic aneurysm (AAA) are based on clinical factors, such as age and smoking history, but do not include biological factors that may better reflect disease pathogenesis.

Objectives

We sought to determine whether a proteomic risk score (ProRS) incorporating plasma protein abundance could improve prediction of AAA.

Methods

We performed a cross-sectional analysis of nearly 37,000 participants in the UK Biobank Pharma Proteomics Project with plasma protein abundance data for 274 cardiometabolic proteins. ProRS models were developed using regularized regression.

Results

The generated sparse ProRS contained well-established clinical risk factors as well as a single protein - matrix metalloproteinase 12 (MMP12). Overall perf

SUBMITTER: Clark MG 

PROVIDER: S-EPMC12723986 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature