Prolonged Loss of Oxidative Phosphorylation and Mitochondrial Mass Characterize CD66b⁺ Leukocytes from Patients with Sepsis.

ABSTRACT:

Introduction

Sepsis leads to expansion of myeloid-derived suppressor cells (MDSC) and their subtypes. These normally transitory MDSCs suppress T cell activation and alter T cell cytokine production while simultaneously promulgating systemic low-grade inflammation. Immune metabolism can shape cell responses, regulate immune suppression, and enhance effector activity. Although MDSC metabolism has been extensively studied in cancer, the metabolic phenotype of this heterogeneous population in sepsis remains unclear. Our goal was to assess metabolic flux in blood MDSCs during and after sepsis and to stratify these patients' clinical features and outcome with differences in metabolic flux that may guide treatment decisions.

Methods

Peripheral blood mononuclear cells (PBMC) from he

SUBMITTER: Rodhouse C 

PROVIDER: S-EPMC12723989 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature