The association between levonorgestrel intrauterine devices and female fertility compared to other contraceptive methods: A historical cohort study.

ABSTRACT:

Objective

This study aimed to investigate whether the use of levonorgestrel intrauterine devices (LNG-IUD) is associated with an increased need for medically assisted reproductive (MAR) treatment compared to other contraceptive methods.

Methods

This register-based historical cohort study included 733 875 Danish women aged 18-42 years between 2000 and 2018. The primary outcome was initiation of MAR treatment in the public healthcare sector. The exposure was categorized as the use of either LNG-IUD, copper (Cu)-IUD, progesterone-only pills (POPs) or combined oral contraceptive pills (OCPs) during the study period. Cox proportional hazard regression was used to assess the risk of initiation of MAR treatment after LNG-IUD use relative to other contraceptive methods.

Results</

SUBMITTER: Michaelsen MP 

PROVIDER: S-EPMC12724036 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature