Prostaglandin dose and time to fetal expulsion after intrauterine fetal death at 22 to 28 gestational weeks in Sweden: A retrospective cohort study.

ABSTRACT:

Objective

Prostaglandin regimens for induction of intrauterine fetal death (IUFD) <28 gestational weeks (GW) are unstandardized. We aimed to describe prostaglandin regimens for induction after IUFD and assess association between dose and time to fetal expulsion.

Methods

We performed a retrospective cohort study among all singleton IUFD 22-28 GW in the Stockholm region, Sweden, 2008-2015. The cumulative prostaglandin dose within 6 h was categorized as a low-, medium-, or high (equivalent to ≤200 μg, >200 μg but <800 μg, or ≥800 μg of misoprostol) based on variations in current clinical guidelines. Our primary outcome was time to fetal expulsion >12 h assessed using multinomial logistic regression adjusting for parity, age, gestational age, Bishop score and previous cesarean s

SUBMITTER: Berger F 

PROVIDER: S-EPMC12724047 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature