Application of the Lancet Commission Criteria for the Diagnosis of Obesity to a Clinical Trials Population: The LEAP Trial.

ABSTRACT:

Objective

This study aimed to apply The Lancet Diabetes & Endocrinology criteria for diagnosing obesity among clinical trial participants and understand participants' characteristics by obesity status.

Methods

The criteria were operationalized and applied to baseline data from the Long-term Effectiveness of the Anti-obesity medication Phentermine (LEAP) trial (NCT05176626). Excess adiposity, organ and tissue dysfunction, and limitations to daily activities were assessed. We examined differences between participants with "no obesity," "pre-clinical obesity," and "clinical obesity."

Results

Among the 860 participants, 0.8% had no obesity (mean BMI 29.0 kg/m² [SD 0.6]), 18.7% had pre-clinical obesity (mean BMI 35.2 kg/m² [SD 3.5]), and 80.5% had cli

SUBMITTER: Heeren FAN 

PROVIDER: S-EPMC12724050 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature