Effect of Zoledronic Acid on Skeletal Muscle After Bariatric Surgery: A Secondary Analysis From a Randomized Controlled Trial.

ABSTRACT:

Objective

This study aimed to investigate whether a single infusion of 5 mg zoledronic acid, given before bariatric surgery to prevent bone loss, could also hinder the loss of muscle mass, strength, and physical function.

Methods

In this double-blinded study, patients referred for bariatric surgery were randomized 1:1 to either intervention (INT: single dose zoledronic acid 5 mg) or placebo (CON). Assessments were conducted at baseline and 12 months postoperatively. The outcomes were body composition (DXA), muscle strength for knee extensor (KE) and knee flexor (KF), and physical function.

Results

Fifty-nine patients (age: 48.9 ± 6.3 years, BMI: 42.3 ± 5.3 kg/m²) were allocated to INT (n = 31) or CON (n = 28). At 12 months, no between-group differences were

SUBMITTER: Gam S 

PROVIDER: S-EPMC12724060 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature