Automated synthetic contrast-enhanced MRI improves choroid plexus segmentation in Parkinsonian syndromes.

ABSTRACT:

Background

Choroid plexus (ChP) has gained attention as a potential biomarker in neurodegenerative diseases, yet its segmentation remains challenging. Gadolinium-based contrast-enhanced MRI (CE-MRI) is the reference standard, as non-contrast MRI images lack sufficient contrast. However, gadolinium deposition, risk of nephrogenic system fibrosis in renally impaired patients, and patient discomfort limit its repeated administration.

Purpose

To develop deep learning-based synthetic-contrast-enhanced MRI (SynCE-MRI) using T1-weighted images to improve ChP visualization and evaluate its ability to detect morphological changes in Parkinsonian syndromes.

Materials and methods

This retrospective study included 265 (mean age = 65.7 ± 7.00 years, males/females: 120/145) consecu

SUBMITTER: Ambaye DT 

PROVIDER: S-EPMC12724087 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature