Genetic diversity and phylogenetic characteristics of human adenovirus strains 40/41 circulating in Yantai, China, during 2017-2019.

ABSTRACT: This study systematically characterizes the genetic diversity, phylogenetic relationships, recombination events, and structural variations of human adenovirus serotypes 40 and 41 (HAdV-F40/41) circulating in Shandong Province, China, between 2017 and 2019. A total of 2,221 stool samples were collected from patients presenting with acute gastroenteritis in Yantai. Enteric adenoviruses were identified using real-time quantitative PCR targeting the hexon gene. Whole-genome sequencing was performed via nanopore and Illumina platforms, enabling high-resolution phylogenetic reconstruction with IQ-TREE and the identification of recombination events using RDP5 and SimPlot. Evolutionary dynamics were inferred through Bayesian molecular clock analysis, while AlphaFold3-based structural modeling was

SUBMITTER: Niu P 

PROVIDER: S-EPMC12724127 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature