Transcription regulator TrtA modulates oxygen stress response in <i>Treponema denticola</i>.

ABSTRACT: Periodontitis is caused by dysbiosis of the subgingival microbiome. Treponema denticola is an obligate anaerobe frequently detected in advanced periodontal lesions. However, the mechanism by which T. denticola evades oxygen stress remains unclear. TDE_0127 (trtA) encodes a potential transcriptional regulator in T. denticola and is upregulated in response to oxygen exposure. However, its exact function is unclear. This study aimed to investigate the involvement of TrtA in the oxygen stress response of T. denticola. trtA expression increased under oxygen exposure. RNA-seq analysis revealed that the expression levels of 38 genes, including that encoding internalin-related protein, were significantly upregulated under anaerobic conditions, and 153 genes, incl

SUBMITTER: Kitamura Y 

PROVIDER: S-EPMC12724145 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature