Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies <i>MMP16</i> and <i>KCTD15</i> as risk loci.

ABSTRACT:

Background

Anthracyclines are a widely used and effective class of chemotherapy. However, a major limitation for their use is cardiotoxicity, manifesting as systolic dysfunction, congestive heart failure (HF) and arrhythmias.

Objective

Identify genes and genetic risk variants for doxorubicin-induced arrhythmia.

Methods

We performed genome-wide association studies (GWAS) and meta-analysis across two independent non-overlapping, genetically homogenous datasets from the Molecular Epidemiology Resource (MER, cases N=77, controls, N=1,184) and Tapestry, (cases N=13, controls, N=172). Doxorubicin-related arrhythmia was the primary cardiac outcome followed by investigation of a broader phenotype of cardiac events. Effects of doxorubicin on top associated genes were assessed

SUBMITTER: Reddy JS 

PROVIDER: S-EPMC12724149 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature