Associations of Epigenetic Age Acceleration with Motor Impairment: Evidence from the PPMI Cohort.

ABSTRACT:

Objective

Motor decline is a hallmark of Parkinson's disease (PD) and biological aging. While epigenetic clocks measure systemic biological aging, their specific relationship with neuromotor function in the context of aging and neurodegeneration remains under-characterized. This study utilized data from the Parkinson's Progression Markers Initiative (PPMI) to examine the relationships between multiple DNA methylation-based epigenetic aging measures and motor impairment across distinct domains.

Methods

We utilized longitudinal phenotype and whole-blood DNA methylation data from the PPMI cohort. Seven epigenetic aging measures were calculated, including first-generation clocks (Horvath v1, Hannum), risk-optimized second-generation clocks (PhenoAge, GrimAge v1 and v2), a deep-l

SUBMITTER: Jiang T 

PROVIDER: S-EPMC12724155 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature