Immunogenic <i>Streptococcus equi</i> cell surface proteins identified by ORFeome phage display.

ABSTRACT: Equine strangles caused by Streptococcus equi subspecies equi (S. equi) remains a significant cause of morbidity and mortality in horses, and there is a need for improved diagnostic and vaccination strategies for addressing this pathogen. ORFeome phage display is a platform that allows for rapid screening for potential antigenic epitopes by construction of phage-displayed peptide libraries. In this study, an S. equi ORFeome library was used to screen serum from a panel of 17 horses with known exposure to S. equi to identify antigenic bacterial proteins. From this screen, three major S. equi proteins were identified: a novel proline-rich repeat domain protein, a serine peptidase, and the M-like protein SeM. These three proteins are predicted to be e

SUBMITTER: Wan J 

PROVIDER: S-EPMC12724188 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature