Pathogenic dengue virus TW2015 strain infection triggers anaerobic glycolysis and enhances mortality in diabetic mice.

ABSTRACT: Dengue virus (DENV) strains with high pathogenicity and transmissibility pose significant public health challenges, especially in tropical and subtropical regions. Underlying conditions such as diabetes mellitus and renal diseases significantly increase the risk of severe dengue. The DENV-2 strain, responsible for a severe outbreak in Taiwan in 2015, exhibits enhanced pathogenicity and transmissibility in a mosquito-mouse transmission model. In this study, we demonstrated that pathogenic DENV infection leads to elevated lactate levels and hypoglycemia in mice, correlating with increased mortality in streptozotocin-induced diabetic models. In infected cells, pathogenic DENV induces rapid eIF2α phosphorylation, extensive ER membrane aggregation, disrupted calcium transfer to mitochondria, an

SUBMITTER: Kuo Y-P 

PROVIDER: S-EPMC12724219 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature