Equine histones are mobilized within equid alphaherpesvirus 1 (EHV1) replication compartments.

ABSTRACT: Equid alphaherpesvirus 1 (EHV1) is a DNA virus that causes severe disease in equids. Some strains are neurotropic and cause disease in the central nervous system, whereas others are non-neurotropic and can cause negative reproductive outcomes. Mechanisms governing EHV1 pathotype are not understood. However, EHV1 pathotypes have different infection efficiencies and replication kinetics in various cell types. They are also differentially susceptible to epigenetic inhibitors. Aside from this observation little is known about EHV1 chromatin or how its regulation influences infection. To build knowledge of EHV1 chromatin, we characterized equine histone mobility during EHV1 infection of equine cells using fluorescence recovery after photobleaching. We show that non-neurotropic or neurotropic EH

SUBMITTER: Conn KL 

PROVIDER: S-EPMC12724232 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature