Development of population pharmacokinetic models of total and free piperacillin in critically ill children and young adults for Monte Carlo simulations and model-informed precision dosing.

ABSTRACT:

Objectives

We sought to develop population pharmacokinetic (PopPK) models of total and free piperacillin in critically ill children and young adults. We investigated the impact of kidney function and injury biomarkers and the effect of time on pharmacokinetic (PK) parameters.

Methods

We enrolled patients admitted to a paediatric ICU and prescribed piperacillin/tazobactam. We collected residual blood from clinical samples for total and free piperacillin concentrations. PopPK models were developed using nonlinear mixed effects modelling. Specific covariates of interest included time after antibiotic initiation, using a 48 h threshold, and urine neutrophil gelatinase-associated lipocalin (uNGAL), a tubular injury biomarker. Monte Carlo simulations investigated target attainment

SUBMITTER: Tang Girdwood S 

PROVIDER: S-EPMC12724257 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature