Pathogenesis of Hazara orthonairovirus infection in type I interferon receptor-deficient mice and resolution of disease following 4'-fluorouridine therapy.

ABSTRACT: The Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a widespread tick-borne agent that causes severe disease in humans. Its expanding geographic range poses a significant public health threat. Although animal models for CCHFV infection have been developed, the requirement for maximum biosafety level 4 facilities limits the development of countermeasures against the virus. Hazara virus (HAZV) is a closely related orthonairovirus that can be handled in biosafety level 2 containment and has been proposed as a prototype virus for the Orthonairovirus genus to facilitate early-stage countermeasure development against the highly pathogenic CCHFV. Here, we present a detailed characterization of HAZV infection in mice deficient in type I interferon signaling (Ifnar^-/-

SUBMITTER: Murray JS 

PROVIDER: S-EPMC12724280 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature