Host interactions of <i>Lactococcus lactis</i> and <i>Streptococcus thermophilus</i> support their adaptation to the human gut microbiota.

ABSTRACT: Within the human gut microbiota, lactic acid bacteria (LAB) play a crucial role in host health by producing lactic acid, which has been shown to shape microbial interactions and support intestinal homeostasis. However, despite their importance, there are limited insights regarding how LAB species interact with the host and other gut commensals. In this study, the investigation of the human gut microbiota of 10,000 healthy adults allowed the identification of Lactococcus lactis and Streptococcus thermophilus as commonly detected food bacteria. Further in silico analyses led to the identification of reference strains of the L. lactis and S. thermophilus species within the human gut, represented by PRL2024 and PRL2025 strains, respectively, which can represe

SUBMITTER: Lugli GA 

PROVIDER: S-EPMC12724283 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature