Regulation of a nickel tolerance operon conserved in <i>Mesorhizobium</i> strains from serpentine soils.

ABSTRACT: The Mesorhizobium nre (nickel resistance) operon has previously been shown to mediate Ni tolerance in serpentine soils with naturally high concentrations of this transition metal. In most serpentine-derived strains evaluated, the putative efflux genes nreX and nreY are conserved, along with a small gene (nreA) encoding a CsoR/RcnR-family transcriptional regulator. CsoR/RcnR-family regulators are small (around 100 amino acids in length); they bind transition metals; and they use an unconventional and poorly understood DNA-binding mechanism. NreA is 93 amino acids in length and belongs to a poorly characterized clade within the CsoR/RcnR family. This investigation is focused on regulatory DNA elements that functionally interact with Mesorhizobium NreA, as w

SUBMITTER: Jensen KT 

PROVIDER: S-EPMC12724321 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature