Non-proteinogenic β-alanine metabolism in <i>Halomonas</i> sp. MNB13 regulates manganese reduction in deep-sea ferromanganese nodules.

ABSTRACT: Deep-sea ferromanganese nodules are valuable materials for investigating microorganism-mediated geochemical cycling of manganese. While many microbial metabolic pathways are closely associated with manganese reduction, few studies have examined the role of amino acid metabolism in the release of Mn(II) from these nodules. Here, we explored the impact of non-proteinogenic β-alanine metabolism on manganese reduction. Halomonas sp. MNB13 is an indigenous bacterium isolated from a ferromanganese nodule that can reduce Mn oxides and decrease the pH of the environment during Mn(II) release. Comparative transcriptomic analysis unveiled that exposure to MnO₂ significantly upregulated β-alanine metabolism, leading to a reduced intracellular concentration of β-alanine. Exogenous β-

SUBMITTER: Guo S 

PROVIDER: S-EPMC12724341 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature