A SUMO interacting motif in the replication initiator protein of tomato yellow leaf curl virus is required for viral replication.

ABSTRACT: Circular Rep-encoding single-stranded (CRESS)-DNA viruses comprise a diverse group of viruses that use rolling-circle replication to copy their genomes. They infect organisms in almost all branches of the eukaryotic tree of life. A hallmark of all CRESS-DNA viruses is the presence of a single conserved protein, the replication initiator protein (Rep), that orchestrates viral replication by exploiting the host DNA replication machinery. In the case of the plant-infecting Geminiviridae, this multifunctional protein both recruits the host DNA replication machinery and manipulates post-translational modification including small ubiquitin-like modifier (SUMO) conjugation. In fact, Rep from two different geminiviruses, tomato yellow leaf curl virus (TYLCV; Begomovirus coheni) and t

SUBMITTER: Gaertner NF 

PROVIDER: S-EPMC12724345 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature