Evidence of transmission and dissemination of diverse <i>bla</i>_NDM-5-producing <i>Escherichia coli</i> clones between refugee and host communities and their environment: a multicenter cross-sectional study.

ABSTRACT: The global spread of carbapenemase-producing Escherichia coli (CP-Ec) poses a significant public health threat, with particularly severe consequences for vulnerable populations in resource-limited settings. To address this, we conducted in-depth genetic analyses and examined the relatedness of CP-Ec isolates recovered from hospitalized patients, refugees, animals, water, and environmental sources within refugee camps and in marginalized host communities in Lebanon. Nineteen putative CP-Ec isolates, identified by MALDI-TOF MS and designated as community isolates, harbored either NDM (n = 17) or OXA-48-like (n = 2) carbapenemases. We used whole-genome sequencing (WGS) to characterize the resistomes and sequence types of these isolates. To further examine genetic relation

SUBMITTER: Fayad S 

PROVIDER: S-EPMC12724354 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature