Global geographic and genomic epidemiology analysis of carbapenem-resistant <i>Escherichia coli</i> carrying <i>bla</i>_NDM-9.

ABSTRACT: Carbapenem-resistant Escherichia coli (CREC), particularly strains producing New Delhi metallo-β-lactamase-9 (NDM-9), pose a growing threat as agents of nosocomial infections. Despite their emergence since 2013, a comprehensive global phylogeographic and genetic characterization of bla_NDM-9-carrying CREC is lacking. Through 7 years (2018-2024) of surveillance of CREC strains in a tertiary hospital, we obtained seven bla_NDM-9-carrying CREC. Antimicrobial susceptibility testing, conjugative transfer experiments, whole-genome sequencing (WGS), and fitness analysis were performed. Publicly available genomes of bla_NDM-9-carrying CREC from NCBI (curated by July 2025) were integrated for global analysis. All seven bla_NDM-9</

SUBMITTER: Sheng J 

PROVIDER: S-EPMC12724373 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature