Antibody-mediated control of anellovirus infection: evidence from people who inject drugs.

ABSTRACT: Infections with viruses belonging to the family Anelloviridae are widespread among humans. Although generally considered a commensal, there is evidence to suggest that these infections may be controlled by host immune responses. However, the mechanism of immune control remains unclear. Previous research has also suggested a possible role of anellovirus capsid spikes in immune evasion. To investigate the role of antibodies in controlling infection, we used AnelloScan to profile plasma collected every 6 months over 2 years from 10 persons who inject drugs (PWID). Participants were selected based on viremia patterns: persistent (n = 6) versus intermittent (n = 4). Long-read metagenomic sequencing revealed a higher median number of alphatorquevirus (TTV) species in partici

SUBMITTER: Kandathil AJ 

PROVIDER: S-EPMC12724376 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature