Insertion of rare autism variants in synaptic genes induce novel behavioral phenotypes in <i>C. elegans</i>.

ABSTRACT: Neurodevelopmental conditions and disorders, including autism, involve a complex interplay of genetic, environmental, and developmental factors. Despite this complexity, genetic studies have identified more than 150 candidate genes that increase risk for autism and related neurodevelopmental and neuropsychiatric conditions. Unsurprisingly, synaptic genes are a large proportion of these genes, likely due to their roles in the formation and maintenance of synaptic architecture, function, and the plasticity of neurons and circuits. The association of synaptic genes with autism and similar conditions is driven by all types of genetic variation, including inherited and de novo rare variants that have unknown impacts on the function of the gene. Here we insert 4 conserved rare variants in

SUBMITTER: Haskell D 

PROVIDER: S-EPMC12724498 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature