Development and Initial Evaluation of 3D-printed High Resolution Brain Phantom for PET.

ABSTRACT: Phantoms are essential for assessing PET system performance, but most existing brain phantoms do not provide the anatomical fidelity required for the next-generation high-resolution PET systems. To address this limitation, we developed HYDRA-OL (HYDrodynamically filled Realistic Anatomy of the Occipital Lobe) phantoms using high-resolution 3D printing based on the BigBrain atlas. In this study, two phantom types were created, HYDRA-OL_G (gray matter only) and HYDRA-OL_GW (gray and white matter), enabling contrast modulation between gray matter (GM) and white matter (WM). Precise anatomical fidelity and repositioning accuracy were confirmed via CT. A custom closed-loop filling apparatus ensured efficient and reproducible phantom preparation. Residual air in the phantom a

SUBMITTER: Lo C 

PROVIDER: S-EPMC12724537 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature