3D printed collimators and dosimetry for spatially fractionated radiation therapy.

ABSTRACT:

Background

Spatially fractionated radiation therapy (SFRT) has shown incredible potential in sparing normal tissues and activating mechanisms of tumor control distinct from conventional radiotherapy. However, the optimal spatial configuration of SFRT as well as the optimal peak and valley dose values have not been established. This poses a barrier to widespread clinical implementation and efficacy.

Purpose

To facilitate greater SFRT optimization, this work establishes a simple, readily customizable, and cost-effective approach for fabricating SFRT collimators with different spatial configurations as well as peak and valley dose values.

Methods

The approach involves fabrication of custom SFRT collimators, each consisting of a 3D-printed plastic shell filled with tungst

SUBMITTER: Coon-Haworth MR 

PROVIDER: S-EPMC12724578 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature