Retention of a single <i>Cenp-C</i> gene in different syntenic locations in the <i>montium</i> group of <i>Drosophila</i> species.

ABSTRACT: Chromosome segregation in eukaryotes requires the orchestrated interaction of chromosomes with microtubules, mediated by the kinetochore multiprotein complex that assembles on specific chromosomal regions known as centromeres. In most eukaryotes, two centromeric proteins, CenH3 and Cenp-C, are essential for centromere function. In Drosophila, the localization of CenH3 (referred to as Cid in Drosophila) depends on its chaperone CAL1 and Cenp-C. Previous studies have shown that both Cid and Cenp-C underwent a coincident gene duplication and likely functional specialization in the Drosophila subgenus. Independently, Cid duplications led to Cid1, Cid3, and Cid4 paralogs in the montium group (Sophophora subgenus), but it is u

SUBMITTER: Soares RF 

PROVIDER: S-EPMC12724597 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature