Connectomic mapping of pharyngeal and gut sensory circuits in adult <i>Drosophila</i>.

ABSTRACT: Feeding is regulated by both external sensory signals, such as taste, and internal sensory signals originating from the pharynx and gut. The recent completion of the Full Adult Fly Brain (FAFB) connectome offers an opportunity to map these sensory inputs and their downstream circuits. While the external gustatory receptor neurons have been relatively well characterized, the internal pharyngeal and gut sensory neurons remain less understood. Here, we systemically identify their axonal projections in the FAFB connectome and examine their downstream circuits. We find that the stomodeal nerve, which carries afferent signals from the gastrointestinal tract to the brain, contains multiple types of sensory axons with distinct morphology and downstream output connections. In addition, we identify

SUBMITTER: Giakoumas DS 

PROVIDER: S-EPMC12724606 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature