Risk for Metachronous Advanced Neoplasia in Patients With a Modified Definition of Advanced Adenoma: Data From the New Hampshire Colonoscopy Registry.

ABSTRACT:

Background & aims

The term "advanced adenoma" (AA) includes adenomas ≥1 cm, ones with villous histology or high-grade dysplasia (HGD), or polyps that may be heterogeneous for metachronous advanced neoplasia (AN) risk (AA and adenocarcinoma). We compared risk in individuals with 10- to 19-mm tubular adenomas (TAs) vs those with HGD, villous histology, and TAs ≥20 mm (modified AAs).

Methods

We used the New Hampshire Colonoscopy Registry to identify individuals having index colonoscopies and follow-up exams 12 months or longer. Outcomes were metachronous AN and subsequent colorectal cancer (CRC). Using Poisson loglinear and Cox proportional hazards models, we compared adjusted metachronous risk of AA and CRC between the 2 AA subgroups and those with lesser findings.

Results<

SUBMITTER: Anderson JC 

PROVIDER: S-EPMC12724626 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature