Membrane-associated periodic skeleton regulates major forms of endocytosis in neurons through a signaling-driven positive feedback loop.

ABSTRACT: Endocytosis is an evolutionarily conserved process that enables neurons to internalize signaling receptors and membrane proteins, maintaining cellular homeostasis and supporting rapid responses to extracellular cues. The neuronal membrane-associated periodic skeleton (MPS), a lattice-like cytoskeletal structure composed of actin and spectrin, has been shown to restrict clathrin-mediated endocytosis (CME) at the axon initial segment (AIS) of neurons, by gating clathrin-coated pit (CCP) formation through membrane-localized "clearing" structures that are devoid of MPS. However, the extent to which the MPS regulates diverse forms of endocytosis across neuronal compartments, and how it is dynamically remodeled to permit trafficking on demand, remain unknown. While CME is relatively well charact

SUBMITTER: Fei J 

PROVIDER: S-EPMC12724672 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature