<i>Enterocloster citroniae</i> and related gut microbiome species modulate <i>Vibrio cholerae</i> biofilm formation through the production of bioactive small molecules.

ABSTRACT: Cholera is a diarrheal disease that affects millions of people globally. Although the causative agent, Vibrio cholerae, has been extensively studied in isolation, investigation of its interactions with the gut microbiota started relatively recently. We and others previously showed that microbiota-derived metabolites significantly influence V. cholerae behavior. By investigating how an organic extract of human feces affects V. cholerae gene expression, we showed that gut metabolites strongly suppress swimming motility, a trait important for host colonization. Interestingly, extracts of pure cultures of a gut commensal, Enterocloster citroniae, recapitulated this inhibition. Here, we present a comprehensive examination of the effect of small molecules produced by

SUBMITTER: Pauer H 

PROVIDER: S-EPMC12724673 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature