Mecp2 deficiency impairs microscale cortical network topology and dynamics in a Rett syndrome mouse model.

ABSTRACT: Rett syndrome is a debilitating neurodevelopmental disorder with cerebral processing impairments caused by MECP2 loss-of-function mutations. Mecp2-deficient mouse models reveal disruptions of microscale cortical circuits. Yet how cellular-scale information processing is altered in Mecp2-deficient microscale functional networks is unknown. We investigated the development of functional connectivity, network topology, and dynamics in microelectrode array (MEA) recordings of primary cortical cultures from Mecp2-deficient and wild-type mice. Mecp2-deficient cortical networks developed more slowly and showed decreased functional connectivity compared to wild-type, leading to smaller network size, density, and strength of connectivity. Altered network topological features in Mecp2-deficien

SUBMITTER: Dunn AWE 

PROVIDER: S-EPMC12724707 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature