Therapeutic mechanisms of genistein in ischemic stroke: A systematic review of in vivo and in vitro studies.

ABSTRACT: Genistein is an isoflavone phytoestrogen that is considered a nutraceutical compound found in soybean. The mimicking of estrogen effects includes the ability to bind to the intracellular and cell membrane receptors of estrogen and exert biological functions like antitumor, anti-inflammatory, anti-oxidative, and antiproliferative properties. With more studies focusing on the therapeutic effect of genistein, both in vitro and in vivo, it is evident that genistein acts through multiple pathways including anti-apoptotic, anti-inflammatory, and anti-oxidative. As the effects of stroke are affecting more people and causing devastating repercussions, this warrants genistein to be utilized as a therapeutic drug. Therefore, further studies are due on the effects of genistein on humans so that clini

SUBMITTER: Mohd Khairudin NY 

PROVIDER: S-EPMC12725566 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature