CD4+ mucosal-associated invariant T cells express highly diverse T cell receptors.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells are highly conserved innate-like T cells in mammals recognized for their high baseline frequency in human blood and cytotoxic effector functions during infectious diseases, autoimmunity, and cancer. While the majority of these cells in humans express a conserved CD8αβ+ TRAV1-2 T cell receptor (TCR) recognizing microbially derived vitamin B2 intermediates presented by the evolutionarily conserved major histocompatibility complex class I-related molecule, MR1, there is an emerging appreciation for diverse MAIT cell subsets that possess distinct functions including CD4+ MAIT cells that remain underexplored. In this study, we adopted an unbiased single-cell TCR-sequencing approach in MR1-5-OP-RU-tetramer-reactive T cells. We discovered that CD4+ MAIT

SUBMITTER: Kaur R 

PROVIDER: S-EPMC12726071 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature