GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain.

ABSTRACT: Neuropathic pain, a major health problem affecting 7-10% of the global population, lacks effective treatment due to its elusive mechanisms. Cholecystokinin-positive (CCK⁺) neurons in the spinal dorsal horn (SDH) are critical for neuropathic pain, yet the underlying molecular mechanisms remain unclear. Here, we show that the membrane estrogen receptor G-protein coupled estrogen receptor (GPER/GPR30) in spinal neurons was significantly upregulated in chronic constriction injury (CCI) mice and that inhibition of GPR30 in CCK⁺ neurons reversed CCI-induced neuropathic pain. Furthermore, GPR30 in spinal CCK⁺ neurons was essential for the enhancement of AMPA-mediated excitatory synaptic transmission in CCI mice. Moreover, GPR30 was expressed in spinal CCK⁺

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12726830 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature