Value-based cognitive control moderates the relation of inflammation with depression in adolescents.

ABSTRACT: Depression has been linked to both elevated systemic inflammation and altered brain function related to reward processing and cognitive control. We know little, however, about how these factors jointly confer risk for this disorder, especially during adolescence, when depressive symptoms typically emerge. In this study, we examined brain function during an incentivized go/no-go task in a community sample of 100 adolescents (mean [SD] = 15.8 [1.1] years). We assessed neural activation and task-dependent functional connectivity using a psychophysiological interaction analysis during the contrast of High Value > Low Value targets in two regions: the ventral striatum (VS) and ventrolateral prefrontal cortex (vlPFC). We hypothesized that activation and functional connectivity in these regions w

SUBMITTER: Yuan JP 

PROVIDER: S-EPMC12726961 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature