Parental Alcohol Use Disrupts Offspring Mitochondrial Activity, Promoting Susceptibility to Toxicant-Induced Liver Cancer.

ABSTRACT: The early onset and incidence of liver disease and hepatocellular carcinoma have doubled in the last two decades and are primarily attributed to an unhealthy lifestyle. However, emerging studies suggest that increases in these age-related pathologies may link to heritable alterations in the control of cellular bioenergetics induced by the parental environment. Because our preclinical studies examining the fetal offspring of alcohol-exposed males and females have consistently identified epigenetic alterations in mitochondrial activity, we hypothesized that chronic parental alcohol exposure programs an increased predisposition of offspring to develop liver disease and hepatocellular carcinoma induced by an environmental toxicant. Here, we employed a multiplex mouse model to compare the sensi

SUBMITTER: Basel A 

PROVIDER: S-EPMC12727083 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature