Circulating Endocannabinoids and Cognitive Function in Older Adults.

ABSTRACT: The role of endogenous cannabinoids (endocannabinoids; eCBs) in cognitive-related processes has been demonstrated in preclinical studies. However, observational studies are lacking. We examined the associations of multiple circulating eCBs and eCB-like molecules with cognitive function in a sample of dementia-free older adults. In this exploratory, cross-sectional study, serum levels of 44 eCBs were analyzed in 237 older participants of the Framingham Heart Study Offspring cohort who attended examination cycle 9 (2011-2014). Linear regression models were used to examine the associations of eCB levels with cognitive function while adjusting for potential confounders and correcting for multiple testing. Effect modification by sex and apolipoprotein ε4 (ApoEε4) was additionally examined. Part

SUBMITTER: Vered S 

PROVIDER: S-EPMC12727136 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature