Estimating risk of reported versus theoretical drug-drug interactions in headaches medicine: an exhaustive comparison between DrugBank and FAERS database for abortive and preventive combinations.

ABSTRACT:

Background

Polypharmacy is common in headache medicine. This project uses DrugBank and Food and Drug Administration's (FDA) Adverse Event Reporting System (FAERS) to determine the likelihood of a theoretical and empirically reported interaction between a given number of headache abortive and preventive medications.

Methods

All headache medications referenced in "The American Headache Society Position Statement on Integrating New Migraine Treatments into Clinical Practice" and Szperka's "Migraine care in the era of COVID-19: clinical pearls and plea to insurers" were included. All possible combinations of up to three abortives and preventatives were screened for drug-drug interactions through searches in DrugBank and FAERS. If at least one drug-drug interaction was listed, th

SUBMITTER: Kaytser V 

PROVIDER: S-EPMC12727184 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature