Nonlinear association of body roundness index with female infertility and the mediating effect of NHHR: A cross-sectional study.

ABSTRACT: The Body Roundness Index (BRI) is an innovative anthropometric measure reflecting body shape and obesity, increasingly recognized as a potential predictor of infertility, warranting further exploration. This research employed a cross-sectional approach using National Health and Nutrition Examination Survey data collected between 2013 and 2018. A weighted multivariate regression model was applied to examine the connection between BRI and infertility risk. To analyze nonlinear trends, weighted restricted cubic splines were implemented, while generalized additive models helped detect threshold effects and inflection points. Subgroup and interaction analyses, adjusted by weights, evaluated specific subgroup roles. Mediation analysis investigated how non-HDL to HDL cholesterol ratio (NHHR) (non

SUBMITTER: Yang W 

PROVIDER: S-EPMC12727249 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature