Antibiotics guided by metagenomic next-generation sequencing to control infection after total knee arthroplasty: A case report and literature review.

ABSTRACT:

Rationale

A prosthetic joint infection is a serious complication of joint surgery, with Staphylococcus aureus being the most common pathogen. In contrast, C. burnetii, the agent of Q fever, is a rare zoonotic parasite primarily found in cattle and sheep. It can be transmitted through respiratory, digestive, and cutaneous routes, destroying host cells and leading to diseases such as bone and joint infections, endocarditis, and interstitial lung disease.

Patient concerns

A 75-year-old male patient underwent total knee arthroplasty due to degenerative disease in his left knee. After surgery, he was exposed to cattle and their feces. Fifteen months after the operation, he experienced pain, though there was no significant elevation of erythrocyte sedimentation rate (ESR), C-react

SUBMITTER: Mei H 

PROVIDER: S-EPMC12727269 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature