Unraveling the genetic association between autoimmune thyroid diseases and idiopathic inflammatory myopathies in the European population.

ABSTRACT: While clinical observations suggest potential links between thyroid autoimmunity disorders (specifically Hashimoto thyroiditis and Graves' disease) and idiopathic inflammatory myopathies (notably dermatomyositis and polymyositis), the underlying causative mechanisms remain incompletely understood. We implemented a Mendelian randomization approach to elucidate potential causal pathways through which thyroid autoimmunity might influence the development of idiopathic inflammatory myopathies. Comprehensive genetic association data regarding thyroid autoimmunity and idiopathic inflammatory myopathies were obtained through systematic extraction from IEU openGWAS project and FinnGen biobank repositories. We identified genetic instruments using stringent selection criteria (P < 5 × 10-8, r2 < 0.01

SUBMITTER: Chang L 

PROVIDER: S-EPMC12727279 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature