Insights into the impact of neuropsychiatric disorders on prostate diseases: A 2-sample Mendelian randomization study.

ABSTRACT: The causal relationship between neuropsychiatric disorders and prostate diseases remains unclear, hindering early identification and intervention for affected patients. This study aims to elucidate the causal relationship between neuropsychiatric disorders and prostate diseases. Sixteen neuropsychiatric disorders and 3 prostate disorders including prostate cancer (PCa), benign prostatic hyperplasia, and prostatitis, were analyzed. Summary statistics of exposures and outcomes were derived from genome-wide association studies, and genetic tools associated with exposures at the genome-wide significance level (P < 5 × 10-8) were extracted for analysis. The inverse variance weighting method was used as the primary approach for Mendelian randomization (MR) analysis, and a mediation MR analysis w

SUBMITTER: Xie H 

PROVIDER: S-EPMC12727309 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature