Exploring the role of immune cell and inflammatory cytokines in the development of rosacea.

ABSTRACT: Immune cells and inflammatory cytokines collectively contribute to the pathogenesis of rosacea. However, the causality between immune cells, inflammatory cytokines and rosacea remains unclear. This study employed Mendelian randomization analysis to investigate the causality among 731 immune cells, 91 inflammatory cytokines, and rosacea. The inverse variance weighted, Mendelian randomization Egger, simple mode, weighted median, and weighted mode analyses were implemented to investigate causality. Sensitivity analyses were conducted to evaluate reliability of findings. Our research results indicated that 3 immune cells can increase risk of rosacea, 4 immune cells can decrease risk of rosacea. Among them, transitional (TR) B cell %lymphocyte (odds ratio [OR] = 1.170, 95% confidence interval [

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12727314 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature