Evaluating the relationship between educational attainment, obesity-related indicators, and prostate diseases: A univariable and multivariable Mendelian randomization study.

ABSTRACT: Recent studies have highlighted the effects of educational attainment (EA) and obesity on health, but their exact causal associations with prostate diseases remain unclear. Therefore, in this study, we performed a Mendelian randomization study to explore these potential relationships. Instrumental variables (IVs) for EA, obesity-related indicators (waist-to-hip ratio [WHR], body mass index, and leptin, and adiponectin [APN] levels), and 3 prostate diseases (benign prostatic hyperplasia [BPH], prostate cancer [PCa], and prostatitis) were selected from genome-wide association studies. Univariate and multivariate Mendelian randomization analyses were performed to investigate and verify the causal relationships. Univariate Mendelian randomization revealed that higher EA levels were related wit

SUBMITTER: Ji WT 

PROVIDER: S-EPMC12727340 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature