Causal role of immunophenotypes in hepatocellular carcinoma: A Mendelian randomization study.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common and fatal malignancies. Immune cell signatures (immunophenotypes) and chronic inflammation have been implicated in HCC pathogenesis. This study aimed to investigate the causal role of immune cell traits in HCC using Mendelian randomization (MR) analysis. A total of 731 immunophenotypes were analyzed using various statistical methods, including the inverse variance weighted method, weighted median method, MR-Egger regression, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier, to assess causal relationships and potential pleiotropy. Forward MR analysis revealed that 4 immunophenotypes, CD28 on CD39+ CD8+ T cells, IgD+ CD38- B cell % lymphocytes, CD4+ CD8dim T cell % leukocytes, and HVEM on central memory CD4+ T cells, had

SUBMITTER: Ou D 

PROVIDER: S-EPMC12727384 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature